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Notwithstanding the above, on occasion these interactions may be sought in order to obtain an improved therapeutic effect.

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The patients' LP showed an inconsistent response to therapy.

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Correlation between urine sodium excretion and SBP rise after tacrolimus treatment, calculated as the change from the average baseline value to the final-day SBP.

Singal AG, Pillai A, Tiro J (2014).

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Data on cyclosporine-treated patients suggest that renin-producing cells may be particularly sensitive to this effect ().

Seizure is a common presentation in the emergency care setting, and new-onset epilepsy is the most common cause of unprovoked seizures.

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Azoles: Voriconazole, posaconazole, itraconazole, ketoconazole, fluconazole and clotrimazole inhibit CYP3A metabolism of tacrolimus and increase tacrolimus whole blood concentrations.

Data were analyzed for the intent-to-treat population (Full Analysis Set; referred to as the overall population), comprising all transplanted and treated patients randomized before a fixed cut-off date; and the per-protocol set (PPS), comprising all patients without major protocol deviations.

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This study revealed the 4-year safety and efficacy of this approach in pediatric recipients.

Chapter 39: Therapeutic Drug Monitoring, Pg 453-463.

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Renal transplantation in the modern immunosuppressive era in Spain: four-year results from a multicenter database focus on post-transplant cardiovascular disease.

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Table summarizes the occurrence of AEs by drug exposure during the core study and during the extension phase of the study.

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