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After radiation to the brain, his crizotinib dose was increased to 250 mg orally twice a day but he had disease progression after 1 month.

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Interestingly, both these genetic alterations of the EGFR are correlated with high probability to respond to anti-EGFR agents.

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The tests use proprietary algorithms developed by Chronix researchers to detect, analyze and identify cancer-related fragments of circulating DNA that are released into the bloodstream by apoptotic cells.

Analysis of DNA fragmentation by flow cytometry: The hypodiploid (sub-G1) fraction was measured using FACS analysis of propidium-iodide-stained cells after overnight fixation with cold 70 % ethanol.

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ISEL was conducted in an unselected patient population before it was known that the EGFR mutation was the target for IRESSA and showed a benefit in only some of the patients.

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